منابع مشابه
Scheduling Coast Guard District Cutters
United States Coast Guard (USCG) districts schedule cutters 180 feet or less in length to weekly statuses (statuses is USCG jargon for assignments) from which they primarily respond to calls for search and rescue, law enforcement, and pollution control. The First Coast Guard District, based in Boston, has one of the largest scheduling problems: Each of 16 cutters is assigned weekly to one of si...
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In this paper, we give a detailed mathematical understanding of flank milling with flat end cutters, which we use to develop a method for milling with such a cutter. This method slides the cutter along two rails, providing two points of contact on the surface.
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Although significant efforts have been directed at developing efficient techniques for rare and super rare genome cutting, only limited success has been achieved. Here we propose a new approach to solve this problem. We demonstrate that peptide nucleic acid 'clamps' (bis-PNAs) bind strongly and sequence specifically to short homopyrimidine sites on lambda and yeast genomic DNAs. Such binding ef...
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This paper describes geometric algorithms for automatically selecting an optimal sequence of cutters for machining a set of 21⁄2D parts. In milling operations, cutter size affects the machining time significantly. Meanwhile, if the batch size is small, it is also important to shorten the time spent on loading tools into the tool magazine and establishing z-length compensation values. Therefore,...
متن کاملOptimization and selection of cutters for 3D pocket machining
The machining of complex geometrical shapes with a CNC machine tool requires the determination of cutting conditions namely the depth of cut, the feed rate, the cutter diameter, the number of cutters in use, etc. The number and the diameter of the cutters used for the machining of a given pocket has an important effect on the machining time. Consequently, it is necessary to have an algorithm fo...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2019
ISSN: 1474-1776,1474-1784
DOI: 10.1038/d41573-019-00116-6